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Biogen

Biogen optimizes drug manufacturing with AVEVA PI System

Biogen aimed to produce enough Aducanumab to treat one million Alzheimer's patients worldwide, a goal that required increasing production, improving yield and reducing costs at the same time. However, the pharmaceutical group lacked the visibility to correct problems in real time and also had to meet particularly strict regulatory requirements. Deploying AVEVA PI System established continuous operational visibility and contextualized information from the plant. Teams implemented real-time review by exception, which allows them to make the necessary adjustments before each batch moves on to the next process step. The benefits are tangible: manufacturing costs are decreasing, yield is increasing and industrial processes can be adjusted on the fly. Biogen is thus strengthening its ability to address a global public health challenge while ensuring the compliance of its operations.

Objectives

  • Making enough Aducanumab to treat one million patients
  • Reduce costs from $10,000 to $100-150 per gram
  • Predict batch quality to make changes in real-time

Solutions

  • AVEVA PI System

Results

  • Setting up a real-time review by exception
  • Reduced manufacturing costs and increased throughput
  • Ability to adjust manufacturing processes in real-time

Testimonials

"Our goal with AVEVA PI System is to make it a central point of information driving some of our really key, data-rich applications and workflows."
Tim Alosi
Head of Global Digital Analytics Team, Biogen

FAQ

How does AVEVA PI System unify data for a multi-site petrochemical group?
Sasol uses AVEVA PI System to centralize operational data from its various production sites in South Africa and internationally. The platform collects process parameters in real time, normalizes them and makes them accessible to all teams: operations, maintenance, engineering and management. This data consolidation is the essential foundation of any digital transformation initiative in the petrochemical industry, where process complexity demands a unified, reliable view.
Why is real-time data management critical in petrochemicals?
In petrochemicals, every process deviation can lead to yield losses, safety risks or product non-compliance. AVEVA PI System allows Sasol to immediately detect deviations, analyze trends and capture operational know-how. High-resolution data traceability also supports environmental regulatory requirements and the demonstration of industrial performance. It is a pillar of operational excellence for a chemical group of this scale.
How does AVEVA PI System foster collaboration between petrochemical teams?
AVEVA PI System makes data accessible through shared dashboards, contextualized notifications and multi-user analysis tools. At Sasol, process engineers, operators and data scientists work from the same source of truth, eliminating silos and speeding up decisions. This data-driven collaboration is a major lever of digital transformation in chemicals, where technical complexity requires cross-functional expertise and smooth sharing of real-time information.
What operational benefits does AVEVA PI System bring to a chemical manufacturer?
For Sasol, AVEVA PI System provides better visibility into production performance, early anomaly detection, energy optimization and fewer unplanned shutdowns. The platform also feeds predictive maintenance and continuous improvement projects. In a sector where margins are under pressure and ESG requirements are growing, these operational gains contribute directly to the competitiveness and long-term viability of the petrochemical business.
Why is the petrochemical industry investing heavily in digital transformation?
The petrochemical sector faces a triple constraint: market volatility, the energy transition and environmental requirements. AVEVA PI System enables manufacturers such as Sasol to turn real-time data into a lever for industrial performance and sustainability. The ability to analyze, model and optimize processes at scale is becoming a key differentiator. That is why data management has become a top-priority strategic investment in modern chemicals.